Clinton was elected in 2000 as the first female senator from New York. Running for president in 2008, she won far more delegates than any previous female candidate, but lost the Democratic nomination to Barack Obama. She helped organize a diplomatic isolation and international sanctions regime against Iran, in an effort to force curtailment of that country's nuclear program; this would eventually lead to the multinational Joint Comprehensive Plan of Action agreement in 2015. efforts during the Space Race and sending a letter to NASA around 1961 asking what she could do to become an astronaut, only to be told that no women were being accepted into the program.
As Secretary of State in the Obama administration from 2009 to 2013, Clinton responded to the Arab Spring, during which she advocated the U. Leaving office after Obama's first term, she wrote her fifth book and undertook speaking engagements. She received the most votes and primary delegates in the 2016 Democratic primaries and formally accepted her party's nomination for President of the United States on July 28, 2016 with vice presidential running mate Senator Tim Kaine. Despite winning a plurality of the national popular vote, Clinton lost the Electoral College and the presidency to her Republican opponent Donald Trump. She was elected class vice president for her junior year, but then lost for class president for her senior year against two boys, one of whom told her that "you are really stupid if you think a girl can be elected president".
As First Lady of the United States, Clinton was an advocate for gender equality and healthcare reform.
Her relationship with her husband came under public speculation during the Lewinsky scandal, forcing her to issue a statement reaffirming her commitment to the marriage.
(Mattis’s statement redraws the red line, threatening reprisal in return for North Korean actions, rather than threats.) The message of this cleanup is that Trump’s statements do not necessarily represent the position of the U. government – a reality most American political elites in both parties already recognize, but which needs to be made clear to other countries that are unaccustomed to treating their head of state like a random Twitter troll.