As well as his twins with her, the hitmaker also shares Cristian, 16, and Ryan, 13, with first wife Dayanara Torres and daughter Ariana, 22, with ex-girlfriend Debbie Rosado.
Meanwhile, the crooner is gearing up for his Full Circle Tour, which kicks off on August 25 in Bridgeport, Connecticut and wraps in Chicago on Deember 3.
Marc filed for divorce from 28-year-old Shannon on December 16, with court documents citing that the marriage was 'irretrievably broken'.
The couple - who wed November 2014 - said in a statement: 'After much consideration, we have mutually and amicably decided to end our two year marriage.' Before Shannon, Marc was married to Jennifer Lopez, and prior to that he was married to Dayanara Torres and Maria Von Ritchie Lopez.
The pooled analysis indicated that circulating adiponectin levels were lower in patients with various cancers than in controls, with a pooled SMD of -0.334 μg/ml (95% CI, -0.465 to -0.203, P = 0.000). Circulating high molecular weight adiponectin levels were also lower in cancer patients than in controls, with a pooled SMD of -0.502 μg/ml (95% CI, -0.957 to -0.047, P = 0.000).
This meta-analysis provides further evidence that decreased adiponectin levels is associated with risk of various cancers.
The You Sang To Me hitmaker has four children from his previous relationships - including twins Emme and Maximillian, eight, with JLo.